英文名稱 | Rocaglamide | Roc-A | MG-002 |
---|---|
中文名稱 | 楝酰胺 |
CAS號(hào) | 84573-16-0 |
分子式 | C29H31NO7 |
分子量 | 505.56 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Rocaglamide | Roc-A | MG-002 |
---|---|
中文名稱 | 楝酰胺 |
CAS號(hào) | 84573-16-0 |
分子式 | C29H31NO7 |
分子量 | 505.56 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.
PMID: 23869022 PMCID: PMC3959726 DOI: 10.1126/science.1238303
PMID: 25333816 PMCID: PMC4237083 DOI: 10.3892/mmr.2014.2718
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells.
PMID: 25333816 PMCID: PMC4237083 DOI: 10.3892/mmr.2014.2718