英文名稱 | Celastrol | Tripterin | Tripterine |
---|---|
中文名稱 | 雷公藤紅素 | 南蛇藤素 |
CAS號 | 34157-83-0 |
分子式 | C29H38O4 |
分子量 | 450.61 |
外觀 | Red crystal powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Celastrol | Tripterin | Tripterine |
---|---|
中文名稱 | 雷公藤紅素 | 南蛇藤素 |
CAS號 | 34157-83-0 |
分子式 | C29H38O4 |
分子量 | 450.61 |
外觀 | Red crystal powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.