Recombinant human IL-7 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 154 amino acids, three pairs of disulfide bonds and having a predicted molecular mass of approximately 17.5kD.
Interleukin 7 (IL-7) is a cytokine involved in the regulation of immune cell development and survival, including T and B lymphocytes. It is produced by stromal cells, such as fibroblasts and bone marrow stromal cells. Dysregulation of IL-7 signaling has been implicated in autoimmune diseases and cancer.