英文名稱 | GDC-0879 |
---|---|
中文名稱 | GDC-0879 |
CAS號 | 905281-76-7 |
分子式 | C19H18N4O2 |
分子量 | 334.37 |
外觀 | White to light brown powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | GDC-0879 |
---|---|
中文名稱 | GDC-0879 |
CAS號 | 905281-76-7 |
分子式 | C19H18N4O2 |
分子量 | 334.37 |
外觀 | White to light brown powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
GDC-0879 is a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC-0879 -treated mice, both cell line- and patient-derived BRAF(V600E) tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.
Potent and selective pyrazole-based inhibitors of B-Raf kinase.
PMID: 18676143 DOI: 10.1016/j.bmcl.2008.07.002
PMID: 19147858 DOI: 10.1124/jpet.108.148189