英文名稱 | NVP-TAE 684 | TAE 684 |
---|---|
中文名稱 | NVP-TAE 684 | TAE 684 |
CAS號(hào) | 761439-42-3 |
分子式 | C30H40ClN7O3S |
分子量 | 614.20 |
外觀 | Light yellow to yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
---|---|---|---|---|---|
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英文名稱 | NVP-TAE 684 | TAE 684 |
---|---|
中文名稱 | NVP-TAE 684 | TAE 684 |
CAS號(hào) | 761439-42-3 |
分子式 | C30H40ClN7O3S |
分子量 | 614.20 |
外觀 | Light yellow to yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM.
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
PMID: 17185414 PMCID: PMC1765448 DOI: 10.1073/pnas.0609412103
PMID: 21502504 PMCID: PMC3088626 DOI: 10.1073/pnas.1019559108
Activating ALK mutations found in neuroblastoma are inhibited by PF-02341066 and NVP-TAE684.
PMID: 21838707 DOI: 10.1042/BJ20101796