英文名稱 | Tovinontrine | IMR-687 |
---|---|
中文名稱 | IMR-687 |
CAS號(hào) | 2062661-53-2 |
分子式 | C21H26N6O2 |
分子量 | 394.47 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
---|---|---|---|---|---|
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英文名稱 | Tovinontrine | IMR-687 |
---|---|
中文名稱 | IMR-687 |
CAS號(hào) | 2062661-53-2 |
分子式 | C21H26N6O2 |
分子量 | 394.47 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively.
PMID: 31147439 PMCID: PMC7049346 DOI: 10.3324/haematol.2018.213462