英文名稱 | CX-5461 dihydrochloride |
---|---|
中文名稱 | CX-5461 dihydrochloride |
CAS號 | N/A |
分子式 | C27H27N7O2S·2HCl |
分子量 | 586.54 | 513.62(free) |
外觀 | Light yellow to yellow powder |
儲存條件 | 4°C, sealed storage, away from moisture |
英文名稱 | CX-5461 dihydrochloride |
---|---|
中文名稱 | CX-5461 dihydrochloride |
CAS號 | N/A |
分子式 | C27H27N7O2S·2HCl |
分子量 | 586.54 | 513.62(free) |
外觀 | Light yellow to yellow powder |
儲存條件 | 4°C, sealed storage, away from moisture |
CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).
PMID: 21159662 DOI: 10.1158/0008-5472.CAN-10-1728
PMID: 22789538 PMCID: PMC3749732 DOI: 10.1016/j.ccr.2012.05.019