英文名稱 | SR-4835 |
---|---|
中文名稱 | SR-4835 |
CAS號 | 2387704-62-1 |
分子式 | C21H20Cl2N10O |
分子量 | 499.36 |
外觀 | Off-white to light brown powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | SR-4835 |
---|---|
中文名稱 | SR-4835 |
CAS號 | 2387704-62-1 |
分子式 | C21H20Cl2N10O |
分子量 | 499.36 |
外觀 | Off-white to light brown powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.
Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer.
PMID: 31668947 DOI: 10.1016/j.ccell.2019.09.004