英文名稱 | MK-0752 |
---|---|
中文名稱 | MK-0752 | 鹽霉素 | 沙利霉素 |
CAS號(hào) | 471905-41-6 |
分子式 | C21H21ClF2O4S |
分子量 | 442.91 |
英文名稱 | MK-0752 |
---|---|
中文名稱 | MK-0752 | 鹽霉素 | 沙利霉素 |
CAS號(hào) | 471905-41-6 |
分子式 | C21H21ClF2O4S |
分子量 | 442.91 |
MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo.
PMID: 20463236 PMCID: PMC2913973 DOI: 10.1523/JNEUROSCI.1381-10.2010
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
PMID: 20068161 PMCID: PMC3442245 DOI: 10.1158/0008-5472.CAN-09-1681
PMID: 22547604 DOI: 10.1200/JCO.2011.39.1540