英文名稱 | RMC-7977 |
---|---|
中文名稱 | RMC-7977 |
CAS號 | 2765082-12-8 |
分子式 | C47H60N8O6S |
分子量 | 865.09 |
外觀 | White to light yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | RMC-7977 |
---|---|
中文名稱 | RMC-7977 |
CAS號 | 2765082-12-8 |
分子式 | C47H60N8O6S |
分子量 | 865.09 |
外觀 | White to light yellow powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
RMC-7977 is a potent, reversible, tri-complex oral inhibitor that selectively targets active (GTP-bound) forms of KRAS, HRAS, and NRAS, which exhibits broad-spectrum activity against both mutant and wild-type variants (a RASMULTI (ON) inhibitor). It also exhibits significant anti-tumor efficacy in pancreatic ductal adenocarcinoma (PDAC).
https://doi.org/10.1182/blood-2023-178397
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
PMID: 38588697 PMCID: PMC11111406 DOI: 10.1038/s41586-024-07379-z
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Research Square; 2023.
https://doi.org/10.21203/rs.3.rs-3122478/v1 PPR: PPR688102