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噁拉戈利

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Elagolix (NBI-56418)

產(chǎn)品編號:CL2564 CAS No.:834153-87-6 MDLNo: 分子式:C32H30F5N3O5 分子量:631.59
規(guī)格 庫存 目錄價(jià) 會員專享價(jià) 數(shù)量
1 mg 3-5days ¥320.00 登錄后可見
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5 mg 3-5days ¥860.00 登錄后可見
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10 mg 3-5days ¥1350.00 登錄后可見
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基本信息
英文名稱 Elagolix (NBI-56418)
中文名稱噁拉戈利
CAS號834153-87-6
分子式C32H30F5N3O5
分子量631.59
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Elagolix (formerly NBI56418; ABT620; NBI-56418; ABT-620; trade name: Orilissa) is a potent, specific, orally bioavailable, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) used for pain management. It inhibits GnRHR with a Kd of 54 pM. Elagolix was given FDA approval on July 23, 2018, to treat endometriosis-related moderate to severe pain. A short-acting GnRH antagonist, elagolix suppresses ovarian estrogen production in a dose-dependent manner, resulting in partial suppression at lower doses and complete suppression at higher doses. Because Elagolix is non-peptide and readily absorbed through the mouth, it is considered the leader of a new class of GnRH inhibitors known as second-generation inhibitors.

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