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奧利司他

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Orlistat

產(chǎn)品編號:CL2557 CAS No.:96829-58-2 MDLNo: 分子式:C29H53NO5 分子量:495.73
規(guī)格 庫存 目錄價(jià) 會員專享價(jià) 數(shù)量
5 g 3-5days ¥200.00 登錄后可見
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10 g 3-5days ¥300.00 登錄后可見
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25 g 3-5days ¥500.00 登錄后可見
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基本信息
英文名稱 Orlistat
中文名稱奧利司他
CAS號96829-58-2
分子式C29H53NO5
分子量495.73
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Orlistat (also known as tetrahydrolipstatin, or Ro 18-0647, Lipase Inhibitor, THL ) is a potent and general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. Orlistat is a drug designed to treat obesity. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. Mechanistic studies suggest that Orlistat inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually Orlistat affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary.

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