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Sotuletinib (BLZ945)

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Sotuletinib (BLZ945)

產(chǎn)品編號：CL2550 CAS No.：953769-46-5 MDLNo： 分子式：C20H22N4O3S 分子量：398.48
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
5 mg 3-5days ￥600.00 登錄后可見
- +
10 mg 3-5days ￥900.00 登錄后可見
- +
25 mg 3-5days ￥1600.00 登錄后可見
- +

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基本信息
英文名稱 Sotuletinib (BLZ945)
中文名稱Sotuletinib (BLZ945)
CAS號953769-46-5
分子式C20H22N4O3S
分子量398.48
外觀Off-white to light brown powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Sotuletinib (formerly BLZ945; BLZ-945) is a novel, potent, selective, orally bioactive, and brain-penetrant CSF-1R (colony stimulating factor 1 receptor) inhibitor with potential antitumor activity. It exhibits 1000-fold higher selectivity against its closest receptor tyrosine kinase homologs and inhibits CSF-1R with an IC50 of 1 nM. Glioma-bearing mice demonstrate high in vivo antitumor efficaciousness of BLZ945. Sotuletinib was designated as an orphan drug by the US FDA in August 2022 in order to treat patients suffering from Amyotrophic Lateral Sclerosis (ALS), a progressive neurological disorder that affects nerve cells in the brain and spinal cord and results in loss of motor control.

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