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首頁 > 產(chǎn)品目錄 > 信號通路 > JAK/STAT 信號通路 > JAK > 奧拉替尼馬來酸鹽 (1208319-27-0)

奧拉替尼馬來酸鹽 (1208319-27-0)

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Oclacitinib Maleate (PF-03394197 Maleate)

產(chǎn)品編號：CL2531 CAS No.：1640292-55-2 MDLNo： 分子式：C19H27N5O6S 分子量：453.51
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
5 mg 3-5days ￥650.00 登錄后可見
- +
10 mg 3-5days ￥975.00 登錄后可見
- +
25 mg 3-5days ￥1800.00 登錄后可見
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基本信息
英文名稱 Oclacitinib Maleate (PF-03394197 Maleate)
中文名稱奧拉替尼馬來酸鹽 (1208319-27-0)
CAS號1640292-55-2
分子式C19H27N5O6S
分子量453.51
外觀White to off-white powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.

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