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首頁(yè) > 產(chǎn)品目錄 > 信號(hào)通路 > PI3K/Akt/mTOR > mTOR > 9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮

9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮

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Torin 2

產(chǎn)品編號(hào):CL2496 CAS No.:1223001-51-1 MDLNo: 分子式:C24H15F3N4O 分子量:432.40
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg 3-5days ¥620.00 登錄后可見(jiàn)
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10 mg 3-5days ¥950.00 登錄后可見(jiàn)
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25 mg 3-5days ¥1660.00 登錄后可見(jiàn)
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基本信息
英文名稱 Torin 2
中文名稱9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮
CAS號(hào)1223001-51-1
分子式C24H15F3N4O
分子量432.40
外觀White to light yellow powder
儲(chǔ)存條件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for mTOR with a superior pharmacokinetic profile to previous inhibitors ((EC50 = 0.3 nM). It has been shown that Torin-2 displayed dramatic antiproliferative activity across a panel of cancer cell lines. Torin-2 showed a powerful cytotoxic activity, inhibiting the growth of each cell line in a dose-dependent manner, with an IC?? in the nanomolar range. Torin-2 caused both apoptosis and autophagy, induced cell cycle arrest in G?/G? phase and affected both mTORC1 and mTORC2 activities.

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