英文名稱 | PF-03814735 |
---|---|
中文名稱 | PF-03814735 |
CAS號 | 942487-16-3 |
分子式 | C23H25F3N6O2 |
分子量 | 474.48 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | PF-03814735 |
---|---|
中文名稱 | PF-03814735 |
CAS號 | 942487-16-3 |
分子式 | C23H25F3N6O2 |
分子量 | 474.48 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
PF-03814735 (PF03814735) is a reversible, orally bioavailable, and ATP-competitive inhibitor of Aurora A/B kinases with potential antitumor activity. It inhibits Aurora A/B with IC50of 0.8 nM and 5 nM, respectively. PF-03814735 showed less potency against Flt3, FAK, TrkA, Met and FGFR1. It exhibits potent in vitro antiproliferative activity and high in vivo antitumor efficacy.