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Linsitinib (OSI-906)

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Linsitinib (OSI-906)

產(chǎn)品編號:CL2468 CAS No.:867160-71-2 MDLNo: 分子式:C26H23N5O 分子量:421.49
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
1 mg 3-5days ¥500.00 登錄后可見
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5 mg 3-5days ¥980.00 登錄后可見
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10 mg 3-5days ¥1600.00 登錄后可見
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基本信息
英文名稱 Linsitinib (OSI-906)
中文名稱Linsitinib (OSI-906)
CAS號867160-71-2
分子式C26H23N5O
分子量421.49
外觀White to yellow powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Linsitinib (formerly OSI-906; OSI 906) is a firs-in-class, ATP-competitive and orally bioavailable dual inhibitor of and insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) with potential antitumor activity. It exhibits modest potency against InsR with an IC50 of 75 nM, and it has no activity against other kinases like Abl, ALK, BTK, EGFR, FGFR1/2, PKA, and so on. In cell-free assays, it inhibits IGF-1R with an IC50 of 35 nM.

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