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艾曲波帕 | 伊屈潑帕 | 艾曲波帕游離堿

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Eltrombopag | Eltrombopag Free Base

產(chǎn)品編號:CL2444 CAS No.:496775-61-2 MDLNo: 分子式:C25H22N4O4 分子量:442.47
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
10 mg In-stock ¥550.00 登錄后可見
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25 mg In-stock ¥880.00 登錄后可見
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50 mg In-stock ¥1408.00 登錄后可見
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基本信息
英文名稱 Eltrombopag | Eltrombopag Free Base
中文名稱艾曲波帕 | 伊屈潑帕 | 艾曲波帕游離堿
CAS號496775-61-2
分子式C25H22N4O4
分子量442.47
外觀Yellow to orange powder
儲存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Eltrombopag (formerly SB-497115; SB 497115; SB497115; trade name PROMACTA), a member of the biarylhydrazone class, is a novel nonpeptide agonist of the thrombopoietin receptor (TpoR) approved for use in the treatment of chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP). Eltrombopag demonstrates an EC50 of 0.27 μM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR. Eltrombopag activates the receptor by association with metal ions (i.e., Zn2+) and specific amino acids within the transmembrane and juxtamembrane domains of the TpoR.

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