英文名稱 | Saracatinib(AZD0530) |
---|---|
中文名稱 | 塞卡替尼 |
CAS號 | 379231-04-6 |
分子式 | C27H32ClN5O5 |
分子量 | 542.03 |
外觀 | White to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Saracatinib(AZD0530) |
---|---|
中文名稱 | 塞卡替尼 |
CAS號 | 379231-04-6 |
分子式 | C27H32ClN5O5 |
分子量 | 542.03 |
外觀 | White to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival.
Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases.