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首頁(yè) > 產(chǎn)品目錄 > 信號(hào)通路 > Apoptosis | 細(xì)胞凋亡 > Bcl-2 > Navitoclax (ABT-263)

Navitoclax (ABT-263)

Navitoclax (ABT-263)

產(chǎn)品編號(hào):CL2346 CAS No.:923564-51-6 MDLNo: 分子式:C47H55ClF3N5O6S3 分子量:974.61
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg In-stock ¥480.00 登錄后可見
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10 mg In-stock ¥760.00 登錄后可見
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基本信息
英文名稱 Navitoclax (ABT-263)
中文名稱Navitoclax (ABT-263)
CAS號(hào)923564-51-6
分子式C47H55ClF3N5O6S3
分子量974.61
外觀White to light yellow powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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