英文名稱 | Nolatrexed dihydrochloride |
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中文名稱 | 二鹽酸諾拉曲塞 |
CAS號 | 152946-68-4 |
分子式 | C14H14Cl2N4OS |
分子量 | 357.26 |
外觀 | Light yellow to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Nolatrexed dihydrochloride |
---|---|
中文名稱 | 二鹽酸諾拉曲塞 |
CAS號 | 152946-68-4 |
分子式 | C14H14Cl2N4OS |
分子量 | 357.26 |
外觀 | Light yellow to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage,S-phase cell cycle arrest, and caspase-dependent apoptosis.This agent also exhibits radiosensitizing activity.