英文名稱 | Teniposide (VM-26) |
---|---|
中文名稱 | 替尼泊苷 |
CAS號 | 29767-20-2 |
分子式 | C32H32O13S |
分子量 | 656.66 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Teniposide (VM-26) |
---|---|
中文名稱 | 替尼泊苷 |
CAS號 | 29767-20-2 |
分子式 | C32H32O13S |
分子量 | 656.66 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle.