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BPTES

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BPTES

產(chǎn)品編號(hào)：CL1972 CAS No.：314045-39-1 MDLNo： 分子式：C24H24N6O2S3 分子量：524.68
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg In-stock ￥250.00 登錄后可見
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10 mg In-stock ￥400.00 登錄后可見
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25 mg In-stock ￥600.00 登錄后可見
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50 mg In-stock ￥1200.00 登錄后可見
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100 mg In-stock ￥1800.00 登錄后可見
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基本信息
英文名稱 BPTES
中文名稱BPTES
CAS號(hào)314045-39-1
分子式C24H24N6O2S3
分子量524.68
外觀White powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1; IC50 = 3.3 μM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493 cells as well as induces cell death, increases the production of reactive oxygen species (ROS), and reduces ATP levels in hypoxic P493 cells. It also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 and/or etomoxir. In vivo, BPTES (12.5 mg/kg) reduces tumor volume in a P493 lymphoma mouse xenograft model.

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