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首頁 > 產(chǎn)品目錄 > 信號通路 > MAPK/ERK Pathway > p38 MAPK > Adezmapimod |SB 203580 | RWJ 64809 | PB 203580

Adezmapimod |SB 203580 | RWJ 64809 | PB 203580

ChemLeader 98+%

Adezmapimod |SB 203580 | RWJ 64809 | PB 203580

產(chǎn)品編號：CL1853 CAS No.：152121-47-6 MDLNo： 分子式：C21H16FN3OS 分子量：377.43

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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
20 mg	In-stock	￥350.00	登錄后可見	- +
50 mg	3-5days	￥600.00	登錄后可見	- +

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基本信息
相關(guān)文檔
產(chǎn)品詳情
相關(guān)文獻

基本信息

英文名稱	Adezmapimod \|SB 203580 \| RWJ 64809 \| PB 203580
中文名稱	Adezmapimod \|SB 203580 \| RWJ 64809 \| PB 203580
CAS號	152121-47-6
分子式	C21H16FN3OS
分子量	377.43
外觀	White to light yellow
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.

相關(guān)文獻

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.

PMID: 10702313 DOI: 10.1074/jbc.275.10.7395

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A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis.

PMID: 24216180 PMCID: PMC3946852 DOI: 10.1016/j.molonc.2013.10.003

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Specificity and mechanism of action of some commonly used protein kinase inhibitors.

PMID: 10998351 PMCID: PMC1221339 DOI: 10.1042/0264-6021:3510095

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Adezmapimod Hydrochloride | SB 203580 Hydrochloride | RWJ 64809 Hydrochloride

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瀏覽記錄

Adezmapimod |SB 203580 | RWJ 64809 | PB 203580

152121-47-6 98+% In-stock

￥350.00 20 mg

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