英文名稱 | Sivelestat Sodium Tetrahydrate | EI546 sodium tetrahydrate | LY544349 sodium tetrahydrate | ONO5046 sodium tetrahydrate |
---|---|
中文名稱 | 西維來司鈉四水合物 | 西維來司他鈉 |
CAS號 | 201677-61-4 |
分子式 | C20H29N2NaO11S |
分子量 | 528.51 |
外觀 | White to off-white powder |
英文名稱 | Sivelestat Sodium Tetrahydrate | EI546 sodium tetrahydrate | LY544349 sodium tetrahydrate | ONO5046 sodium tetrahydrate |
---|---|
中文名稱 | 西維來司鈉四水合物 | 西維來司他鈉 |
CAS號 | 201677-61-4 |
分子式 | C20H29N2NaO11S |
分子量 | 528.51 |
外觀 | White to off-white powder |
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
PMID: 17203197
O-5046, a novel inhibitor of human neutrophil elastase.
PMID: 2049103 DOI: 10.1016/0006-291x(91)91862-7
PMID: 18165924 DOI: 10.1007/s11010-007-9698-9