英文名稱 | Afatinib (BIBW2992) |
---|---|
中文名稱 | 阿法替尼 |
CAS號 | 850140-72-6 |
分子式 | C24H25ClFN5O3 |
分子量 | 485.94 |
外觀 | White solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Afatinib (BIBW2992) |
---|---|
中文名稱 | 阿法替尼 |
CAS號 | 850140-72-6 |
分子式 | C24H25ClFN5O3 |
分子量 | 485.94 |
外觀 | White solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Afatinib inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy.