英文名稱 | Licofelone |
---|---|
中文名稱 | 利克飛龍 |
CAS號 | 156897-06-2 |
分子式 | C23H22ClNO2 |
分子量 | 379.88 |
外觀 | Off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Licofelone |
---|---|
中文名稱 | 利克飛龍 |
CAS號 | 156897-06-2 |
分子式 | C23H22ClNO2 |
分子量 | 379.88 |
外觀 | Off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.