英文名稱 | Siponimod (BAF-312) |
---|---|
中文名稱 | 辛波莫德 |
CAS號 | 1230487-00-9 |
分子式 | C29H35F3N2O3 |
分子量 | 516.60 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Siponimod (BAF-312) |
---|---|
中文名稱 | 辛波莫德 |
CAS號 | 1230487-00-9 |
分子式 | C29H35F3N2O3 |
分子量 | 516.60 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Siponimod, also known as BAF-312, is a a potent and orally selective S1P Receptor Modulator with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively. Development of sphingosine-1-phosphate receptor 1 (S1P1) modulators to dampen inflammation and its sequelae is becoming increasingly promising for treating medical conditions characterized by significant immunopathology.