英文名稱 | A-1155463 |
---|---|
中文名稱 | A-1155463 |
CAS號 | 1235034-55-5 |
分子式 | C35H32FN5O4S2 |
分子量 | 669.79 |
外觀 | Off-white to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | A-1155463 |
---|---|
中文名稱 | A-1155463 |
CAS號 | 1235034-55-5 |
分子式 | C35H32FN5O4S2 |
分子量 | 669.79 |
外觀 | Off-white to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
PMID: 25787766 DOI: 10.1126/scitranslmed.aaa4642
PMID: 26134786 PMCID: PMC4487849 DOI: 10.1186/s12943-015-0397-y
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
PMID: 25313317 PMCID: PMC4190639 DOI: 10.1021/ml5001867