英文名稱 | Cobimetinib (GDC-0973; XL518) |
---|---|
中文名稱 | 考比替尼 |
CAS號 | 934660-93-2 |
分子式 | C21H21F3IN3O2 |
分子量 | 531.31 |
外觀 | Off-white solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Cobimetinib (GDC-0973; XL518) |
---|---|
中文名稱 | 考比替尼 |
CAS號 | 934660-93-2 |
分子式 | C21H21F3IN3O2 |
分子量 | 531.31 |
外觀 | Off-white solid powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, and showing no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Cobimetinib induces apoptosis. Phase 3.