英文名稱 | A-485 |
---|---|
中文名稱 | A-485 |
CAS號 | 1889279-16-6 |
分子式 | C25H24F4N4O5 |
分子量 | 536.48 |
外觀 | White to off-white powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | A-485 |
---|---|
中文名稱 | A-485 |
CAS號 | 1889279-16-6 |
分子式 | C25H24F4N4O5 |
分子量 | 536.48 |
外觀 | White to off-white powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
A-485 is a p300/CBP histone acetyltransferase (HAT) inhibitor that inhibits p300 and CBP (IC50=9.8/2.6 nM) selectively. A-485 has antitumor effects, including several hematologic malignancies and androgen receptor-positive prostate cancer.
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
PMID: 28953875 PMCID: PMC6050590 DOI: 10.1038/nature24028
PMID: 32173363 DOI: 10.1016/j.bcp.2020.113914