英文名稱 | Lenalidomide | CC-5013 |
---|---|
中文名稱 | 來那度胺 |
CAS號 | 191732-72-6 |
分子式 | C13H13N3O3 |
分子量 | 259.26 |
外觀 | Off-white to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Lenalidomide | CC-5013 |
---|---|
中文名稱 | 來那度胺 |
CAS號 | 191732-72-6 |
分子式 | C13H13N3O3 |
分子量 | 259.26 |
外觀 | Off-white to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.