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尼達(dá)尼布乙磺酸鹽

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Nintedanib Ethanesulfonate Salt | Intedanib | BIBF 1120

產(chǎn)品編號(hào)：CL1034A CAS No.：656247-18-6 MDLNo： 分子式：C31H33N5O4.C2H6O3S 分子量：649.76 | 539.64(free)
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
10 mg In-stock ￥300.00 登錄后可見
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25 mg In-stock ￥500.00 登錄后可見
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50 mg In-stock ￥900.00 登錄后可見
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100 mg In-stock ￥1300.00 登錄后可見
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基本信息
英文名稱 Nintedanib Ethanesulfonate Salt | Intedanib | BIBF 1120
中文名稱尼達(dá)尼布乙磺酸鹽
CAS號(hào)656247-18-6
分子式C31H33N5O4.C2H6O3S
分子量649.76 | 539.64(free)
外觀Yellow powder
儲(chǔ)存條件4°C, sealed storage, away from moisture
產(chǎn)品詳情

BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively).1 It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM). BIBF 1120 inhibits growth factor-dependent proliferation of human umbilical vascular endothelial cells (HUVECs), human microvascular skin endothelial cells (HSMECs), human umbilical artery smooth muscle cells (HUASMCs), and bovine retinal pericytes (BRPs; EC50s = 7-290 nM). In vivo, BIBF 1120 (100 mg/kg) reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model. It also inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model. Formulations containing BIBF 1120 have been used in the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer (NSCLC).



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