英文名稱 | Tipranavir | TPV | PNU-140690 |
---|---|
中文名稱 | 替拉那韋 |
CAS號 | 174484-41-4 |
分子式 | C31H33F3N2O5S |
分子量 | 602.66 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Tipranavir | TPV | PNU-140690 |
---|---|
中文名稱 | 替拉那韋 |
CAS號 | 174484-41-4 |
分子式 | C31H33F3N2O5S |
分子量 | 602.66 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tipranavir is a protease inhibitor that inhibits HIV-1 resistant to more than 1 protease inhibitor .Tipranavir effectively inhibits HIV-1 protease enzyme activity and dimerisation and has potent activity against multiple protease inhibitor (PI) HIV-1 isolates (IC50 of 66-410 nM). Tipranavir inhibits SARS-CoV-2 3CLpro activity.
Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice.
PMID: 20103582 PMCID: PMC2872945 DOI: 10.1124/dmd.109.030817
PMID: 23015723 PMCID: PMC3503118 DOI: 10.1128/JVI.07234-11
PMID: 34052830 PMCID: PMC8164054 DOI: 10.1038/s41392-021-00628-x