英文名稱 | Staurosporine | AM-2282 |
---|---|
中文名稱 | 星形孢菌素 | 星孢菌素 |
CAS號 | 62996-74-1 |
分子式 | C28H26N4O3 |
分子量 | 466.53 |
外觀 | White to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Staurosporine | AM-2282 |
---|---|
中文名稱 | 星形孢菌素 | 星孢菌素 |
CAS號 | 62996-74-1 |
分子式 | C28H26N4O3 |
分子量 | 466.53 |
外觀 | White to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Staurosporine (STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc.
The ORF3a Protein of SARS-CoV-2 Induces Apoptosis in Cells.
PMID: 32555321 PMCID: PMC7301057 DOI: 10.1038/s41423-020-0485-9
Molecular mechanism of staurosporine-induced apoptosis in osteoblasts.
PMID: 10987998 DOI: 10.1006/phrs.2000.0700
PMID: 8529658 DOI: 10.1111/j.1432-1033.1995.317_c.x