英文名稱 | Y-27632 (free base) |
---|---|
中文名稱 | Y-27632 |
CAS號 | 146986-50-7 |
分子式 | C14H21N3O |
分子量 | 247.34 |
外觀 | White to off-white powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
英文名稱 | Y-27632 (free base) |
---|---|
中文名稱 | Y-27632 |
CAS號 | 146986-50-7 |
分子式 | C14H21N3O |
分子量 | 247.34 |
外觀 | White to off-white powder |
儲存條件 | -20°C, protect from light, stored under nitrogen |
Y-27632 is a potent and selective inhibitor of ROCK1 (p160ROCK) with IC50 of 140 nM in a cell-free assay, it exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
PMID: 27591478 DOI: 10.1016/j.scr.2016.07.009